AGIO on Nasdaq

Agios Pharmaceuticals

Public American pharmaceutical company

Agios Pharmaceuticals Inc. is a publicly trading American pharmaceutical company pioneering therapies for genetically defined diseases, with a near-term focus on developing therapies for hemolytic anemias.3 From Wikipedia, CC BY-SA 4.0

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Last updated Oct 16, 2026.

Overview

2008Founded1

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  • TickerAGIO on Nasdaq1
  • Industrypharmaceutical industry1
  • HeadquartersCambridge1
  • Websitewww.agios.com
  • Incorporated inDE4
  • Business address88 Sidney Street, Cambridge, Ma 021394
  • Filer categoryLarge accelerated filer4
Agios Pharmaceuticals image from its website
Image: agios.com6

Agios Pharmaceuticals Inc. is a publicly trading American pharmaceutical company pioneering therapies for genetically defined diseases, with a near-term focus on developing therapies for hemolytic anemias. The company was founded in 2008 (or 2007) by Lewis Cantley, Tak Mak and Craig Thompson. Agios is a Delaware corporation headquartered in Cambridge, Massachusetts. The company tendered an initial public offering in July 2013.3

Financials

From the company’s reports to the SEC. Every number links to the filing it came from.

Key numbers, fiscal 2025

-873.9%Operating margin7
-764.0%Net margin7
48.0%Revenue growth, 20257
-34.6%Return on equity7
-$377.3MFree cash flow7

Where the money goes

Where each dollar of revenue went, fiscal 2025

  • Cost of revenue1¢$6.3M
  • Research and development64¢$339.5M
  • Selling, general and admin34¢$180.3M
  • Income tax0¢$1.0M

Out of $54.0M in revenue.7 The company lost money this year.

Financial statements

Revenue8910117$54.0M in 2025−54% since 2019
0$50.0M$100.0M$150.0M2019: $117.9M$117.9M20192020: $0$020202021: $0$020212022: $14.2M$14.2M20222023: $26.8M$26.8M2023+88%2024: $36.5M$36.5M2024+36%2025: $54.0M$54.0M2025+48%
Operating income12910117-$472.1M in 2025+49% since 2019
-$600.0M-$400.0M-$200.0M02019: -$316.3M-$316.3M20192020: -$335.9M-$335.9M2020+6%2021: -$378.4M-$378.4M2021+13%2022: -$389.0M-$389.0M2022+3%2023: -$391.5M-$391.5M2023+1%2024: -$425.7M-$425.7M2024+9%2025: -$472.1M-$472.1M2025+11%
Net income12910117-$412.8M in 2025+0% since 2019
-$1.0B0$1.0B$2.0B2019: -$411.5M-$411.5M20192020: -$327.4M-$327.4M2020−20%2021: $1.6B$1.6B20212022: -$231.8M-$231.8M20222023: -$352.1M-$352.1M2023+52%2024: $673.7M$673.7M20242025: -$412.8M-$412.8M2025

Every line of the income statement in the latest annual report, as filed.7

Period ending2025-12-312024-12-312023-12-31
Total product revenue, net$54.0M$36.5M$26.8M
Cost of sales$6.3M$4.2M$2.9M
Research and development$339.5M$301.3M$295.5M
Total selling, general and administrative expenses$180.3M$156.8M$119.9M
Total operating expenses$526.2M$462.2M$418.3M
Loss from operations-$472.1M-$425.7M-$391.5M
Gain on sale of contingent payments$0$889.1M$0
Milestone payment from gain on sale of oncology business$0$200.0M$0
Interest income, net$56.4M$48.1M$33.3M
Other income, net$2.0M$6.5M$6.1M
Net (loss) income before taxes-$413.8M$718.0M-$352.1M
Income tax (benefit) expense-$1.0M$44.2M$0
Net (loss) income-$412.8M$673.7M-$352.1M
Net income (loss) per share - basic (in usd per share)-$7.12$11.86-$6.33
Net income (loss) per share - diluted (in usd share)-$7.12$11.64-$6.33
Weighted-average number of common shares used in computing net income (loss) per share basic (in shares)58.0M shares56.8M shares55.7M shares
Weighted-average number of common shares used in computing net income (loss) per share diluted (in shares)58.0M shares57.9M shares55.7M shares

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The story

In 2012, Agios was named among the defendants in a lawsuit against one of its founders, Craig Thompson, alleging that Thompson used research illegally taken from the Abramson Family Cancer Research Institute in research at Agios.

In May 2016, the company announced it would launch partnership with Celgene, developing metabolic immuno-oncology therapies and licensing AG-221 as well as AG-881 to Celgene, potentially garnering Agios $120 million in drug licensing payments.

In April 2017, the company raised $250 million in a new stock offering in anticipation of approval for its first cancer drug, enasidenib, by the US Food and Drug Administration.

In December 2017, the company filed a New Drug Application with the US FDA for ivosidenib for the treatment of adult patients with relapsed or refractory acute myeloid leukemia with an IDH1 mutation.

In November 2019, Agios announced an underwritten public offering of 8,250,000 shares of common stock at a price of $31.00 per share which would result in approximately $256 million aggregate gross proceeds.

In April 2022, the FDA approved mitapivat as first disease-modifying therapy for hemolytic anemia in adults with pyruvate kinase deficiency.

From Wikipedia’s article on Agios Pharmaceuticals, shared under CC BY-SA 4.0.5

Former names

  • AGIOS PHARMACEUTICALS INCJul 1, 2008 to Jul 16, 20194

Timeline

  1. Jul 24, 2013Went public Listed on NASDAQ1
  2. 2008Founded Founded1

Recent filings

  1. Aug 6, 20264
  2. Aug 4, 2026144
  3. Aug 3, 2026SCHEDULE 13G/A
  4. Jul 30, 20268-K
  5. Jul 30, 202610-Q
  6. Jul 10, 20264
  7. Jul 2, 20264
  8. Jul 2, 2026SCHEDULE 13G
  9. Jul 1, 2026144
  10. Jun 23, 20264
  11. Jun 23, 20264
  12. Jun 23, 20264
  13. Jun 23, 20264
  14. Jun 23, 20264
  15. Jun 23, 20264

Every filing from the last three years, summarized. The full record is on SEC EDGAR.2