HKX operated at least one train each way each day, from Fridays to Mondays. Fares for the entire route ranged from €20 to €60.
The Hamburg-Köln-Express called at most intermediate stations also served by DB long-distance trains, but left out Düsseldorf Airport and Bremen Hbf. HKX used the freight line bypassing Bremen, reducing journey times to Hamburg. An additional stop at nearby Sagehorn was planned but never introduced.
The trains called only at Osnabrück, Münster, Gelsenkirchen, Essen, Duisburg, and Düsseldorf.
On 14 March 2012 Veolia Verkehr, a subsidiary of Veolia-Transdev, signed an agreement to operate the services under contract to HKX. Veolia provided drivers and locomotives. For a time, services were operated using former Rheingold coaches hauled by leased Siemens ES 64 U2 "Taurus" type electric locos, which were planned to be replaced by refurbished Class 4010 type trainsets formerly owned by ÖBB.
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From December 2015 onwards, the coaches were from Bahn Touristik Express, which also operated the trains under contract to HKX. The locomotive was still a leased ES 64 U2 "Taurus". Services ran at speeds of up to 160 km/h.