SIAL on NASDAQ

Sigma-Aldrich

Logo: Unknown author Unknown author, Public domain, via Wikimedia Commons3

Healthcare company

Sigma-Aldrich (part of MilliporeSigma) is a brand operating within an American chemical, life science, and biotechnology company owned by the multinational chemical conglomerate Merck Group. The life sciences business of Merck Group operates as MilliporeSigma in the United States.2 From Wikipedia, CC BY-SA 4.0

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Last updated Oct 16, 2026.

Overview

1976Founded1

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  • TickerSIAL on NASDAQ1
  • Industrybiotechnology, biotechnology industry1
  • HeadquartersSt. Louis1
  • Websitewww.sigmaaldrich.com
  • Legal formpublic company1

Sigma-Aldrich (part of MilliporeSigma) is a brand operating within an American chemical, life science, and biotechnology company owned by the multinational chemical conglomerate Merck Group. The life sciences business of Merck Group operates as MilliporeSigma in the United States.2

The story

Sigma Chemical Company of St. Louis and Aldrich Chemical Company of Milwaukee were both American specialty chemical companies when they merged in August 1975. The company grew throughout the 1980s and 1990s, with significant expansion in facilities, acquisitions and diversification into new market sectors.

Early history

1935 – Midwest Consultants was founded in St Louis by brothers Aaron Fischer and Bernard Fischlowitz, who hired chemical engineer Daniel Broida.

1946 – Sigma was formed from Midwest Consultants and manufactured just adenosine triphosphate. They were the first to manufacture pure ATP.

1972 – Sigma's IPO

1951 – Aldrich founded in Milwaukee by Alfred Bader and Jack Eisendrath and manufactured just 1-methyl-3-nitro-1-nitrosoguanidine.

1966 – Aldrich's IPO

1972 – Subsidiary Aldrich-Boranes launched to manufacture hydroboration products

1975 – Merger of Sigma Chemical and Aldrich Chemical to created Sigma-Aldrich. Their first year earned $43 million in sales.

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1999 – Sigma-Aldrich reaches $1 billion in sales

2005 – Announced membership in The RNAi Consortium

2014 – Merck KGaA announced that it would purchase Sigma-Aldrich for approx. $17 billion (€13.1 billion).

November 3, 2014 – Sigma-Aldrich filed a definitive proxy statement with the U.S. Securities and Exchange Commission to hold a special investors meeting regarding approval for the sale to Merck KGaA.

1970s

1978 – Makor Chemicals

1980s

1984 – Pathfinder

1986 – Bio Yeda, Bristol Organics

1989 – Fluka Chemie AG (Swiss company founded in the 1950s) purchased for $39 million.

1990s

1993 – Supelco, Inc. acquired to enter the chromatography market

1994 – LabKemi AB

1997 – Research Biochemicals International, Riedel-de-Haen, Techcares Systems, Carbolabs, YA Kemia

1998 – Genosys

2000s

2000 – First Medical Inc., Amelung GmbH, ARK Scientific

2001 – ISOTEC (produces stable isotopes used in basic research and medical diagnostics)

2004 – Ultrafine (a supplier of contract manufacturing services for drug development), Tetrionics (a producer of high potency and cytotoxic active pharmaceutical ingredients)

2005 – JRH Biosciences, an industrial supplier of cell culture products for the pharmaceutical and biotechnology industries; Proligo Group, a global supplier of genomics research tools

2006 – Beijing Superior Chemicals, Iropharm, Pharmorphix, Advanced Separation Technologies (manufacturer of products for chiral chromatography)

2007 – Epichem acquired to expand capabilities in materials sciences and semiconductor markets; Molecular Medicine BioServices acquired to provide large-scale viral manufacturing capabilities; announced alliance with Sangamo BioSciences to develop zinc finger-based laboratory research reagents

2009 – ChemNavigator

2010 – Cerilliant Corporation, ACE Animals

2011 – Resource Technology Corp, Vetec Quimica Fina

2012 – Research Organics Inc., BioReliance (a toxicology and veterinary diagnostics company); BioReliance had previously been acquired by Invitrogen and subsequently sold to Avista Capital Partners.

2014 – Cell Marque

2015 – Combined with EMD Millipore to make MilliporeSigma.

From Wikipedia’s article on Sigma-Aldrich, shared under CC BY-SA 4.0.4

Leadership

Who has led Sigma-Aldrich, and when. Pick a name to see everywhere that person has worked.

Products and brands

Aldrich is a supplier in the research and fine chemicals market. Aldrich provides organic and inorganic chemicals, building blocks, reagents, advanced materials and stable isotopes for chemical synthesis, medicinal chemistry and materials science. Aldrich's chemicals catalog, the "Aldrich Catalog and Handbook" is often used as a handbook due to the inclusion of structures, physical data, and literature references.

Sigma is the Sigma-Aldrich's main biochemical supplier, with offerings including antibiotics, buffers, carbohydrates, enzymes, forensic tools, hematology and histology, nucleotides, proteins, peptides, amino acids and their derivatives.

Sigma RBI produces specialized products for use in the field of cell signaling and neuroscience. Their offerings range from standard biochemical reagents to specialized research tools, including ligands for receptors and ion channels, enzyme inhibitors, phosphospecific antibodies, key signal transduction enzymes, and assay kits for cell signaling.

ISOTEC provides isotopically labeled products for protein structure determination, peptide synthesis, proteomics, metabolic research, magnetic resonance imaging, nuclear magnetic resonance, breath test substrates, agriculture, as well as gas and gas mixes.

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Riedel-de Haën was incorporated with Sigma-Aldrich in 1999 and manufactures reagents and standards.

Supelco is the chromatography products branch of Sigma-Aldrich. It provides chromatography columns and related tools for environmental, government, food and beverage, pharmaceutical, biotechnology, medical and chemical laboratories; sample preparation products and chemical reference standards.

Sigma-Aldrich Fine Chemicals (SAFC) is the fine chemical supply branch of Sigma-Aldrich specializing in raw materials for cell culture products; customized services for raw materials, manufacturing of active pharmaceutical ingredients.

Sigma Life Science provides products such as custom DNA/RNA oligos; custom DNA and LNA probes; siRNA; isotopically-labelled peptides and peptide libraries.

Sigma Advanced Genetic Engineering (SAGE) Labs was a division within Sigma-Aldrich that specializes in genetic manipulation of in vivo systems for special research and development applications. It was formed in 2008 to investigate zinc finger nuclease technology and its application for disease research models. Located in St. Louis, Missouri, SAGE Labs have developed knockout rats for the study of human diseases and disorders (such as autism), which are sold for up to US$95,000. SAGE also announced its first successful effort in creating a "knockout rabbit". Its facilities include a specific pathogen free, biosecure vivarium as well as research and development labs. SAGE Labs was acquired by Horizon Discovery Group in 2014.

Carbolabs produces research quantities of chemicals produced by phosgenation reactions. The company was acquired in 1998.

BioReliance provides testing and manufacturing services to pharmaceutical and biopharmaceutical companies that span the product cycle from early pre-clinical development to licensed production.

The company was acquired by Sigma Aldrich in January 2012.

From Wikipedia’s article on Sigma-Aldrich, shared under CC BY-SA 4.0.4

Subsidiaries and ownership

Parent company

Subsidiaries

  • Sigma-Aldrich (Canada)
  • Supelco Inc
  • Guava Technologies since Feb 2, 2009

From Wikidata.1

Acquisitions

  1. Feb 2, 2009Acquired Guava Technologies1

Timeline

  1. 2015Dissolved Dissolved1
  2. 1976Founded Founded1

Sources

The numbers on this page point here. Each one links to the record it came from.

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