Sophia Genetics

Sophia Genetics was co-founded by Jurgi Camblong, Pierre Hutter, and Lars Steinmetz in 2011 as a start-up at École Polytechnique Fédérale de Lausanne (EPFL). It began as a research tool for hospitals and federally regulated health care labs, and then expanded to biopharma institutions.

In 2014, the company introduced an analytical software platform, the Sophia DDM Platform (Data-Driven Medicine), which helps to interpret circulating tumor DNA and circulating tumour cells in blood, urine, cerebral spinal fluid and other liquid samples. The platform is used for oncology, hereditary cancers, metabolic disorders, pediatrics, cardiology, and for rare disease research.

In 2018, the company set up its first research and development center in France and made acquisition of a France-based molecular biology and genetic analytics software development company, Interactive Biosoftware. That same year, Sophia Genetics opened its U.S. headquarters in Boston, Massachusetts.

Prior to its initial public offering, Sophia Genetics raised approximately $250 million across several private funding rounds. The company closed a $13.75 million Series B round in 2014, led by Invoke Capital, Swisscom, and Endeavour Vision. This was followed by a $15 million Series C round in 2015, led by Belgian entrepreneur Marc Coucke. In September 2017, the company raised $30 million in a Series D round led by Balderton Capital. A $77 million Series E round followed in January 2019, led by Generation Investment Management. The company's largest private round, a $110 million Series F, closed in October 2020, led by aMoon and Hitachi Ventures, bringing its total funding raised since founding to approximately $250 million.

In August 2020, the company released a data analysis solution that was focused on predicting the disease evolution of the SARS-CoV-2 virus. Also in 2022, the firm began development of a new method for detecting extrachromosomal DNA through collaboration with startup firm Boundless Bio.

In July 2021, Sophia Genetics went public with an IPO backed by J.P. Morgan, Morgan Stanley, and Credit Suisse.

In 2014, Sophia Genetics introduced an analytical software platform, the Sophia DDM Platform (Data-Driven Medicine). The data analytics platform allows clinicians to improve genomic diagnostics by applying AI to enhance next-generation sequencing methods. The DDM platform is used for oncology, hereditary cancers, metabolic disorders, pediatrics, cardiology, and for rare disease research. The company initially designed the platform to help hospitals process and store large genomic data sets, but after research showed the more important issue with the technology was data accuracy, the platform's focus shifted.

In 2018, Sophia Genetics acquired Nénuphar, a technology that uses patient data and algorithms to predict tumor growth.

In May 2024, the company announced a collaboration with Microsoft and Nvidia to build a whole-genome sequencing application on the platform, using Nvidia's Parabricks genomics software hosted on Microsoft Azure cloud infrastructure.

In September 2024, the company launched a new generation of the SOPHiA DDM platform, redesigned around a microservices architecture intended to process larger datasets more efficiently. The platform holds CE-IVD certification under the EU In Vitro Diagnostic Regulation (IVDR) for several diagnostic solutions, including hereditary cancer, homologous recombination deficiency (HRD), and RNA-based oncology testing.