1y return+35.4%S&P 500 +20.9%
These returns are for its stock picks as disclosed on Form 13F: last quarter's holdings, valued at this quarter's prices. They miss trades within each quarter, short positions, options, bonds, cash and fees, so they aren't the returns its clients got.
$100 invested in its stock picks
Since March 31, 2024: $166 against $143 in the S&P 500.2
Darwin Global Management, Ltd.S&P 500 (SPY)
Top holdings
At the end of June 30, 2026. Change is in shares since the quarter before.2
| Stock | Value | Share of portfolio | Change |
|---|---|---|---|
| RVMDRevolution Medicines Inc | $2.0B | 54.5% | +380.8% |
| INSMInsmed Inc | $673.6M | 17.9% | −61.7% |
| BLTEBelite Bio Inc | $456.6M | 12.1% | |
| ABVXAbivax Sa | $348.2M | 9.3% | +4.4% |
| Roivant Sciences LtdCUSIP G76279101 | $234.3M | 6.2% |
Best picks still held
How each current holding has done since the quarter it first appeared in its filings (up to six years back).
| Stock | Held since | Return since | Now worth |
|---|---|---|---|
| RVMDRevolution Medicines Inc | March 31, 2026 | +92.6% | $2.0B |
| INSMInsmed Inc | June 30, 2024 | +59.1% | $673.6M |
| ABVXAbivax Sa | September 30, 2025 | +57.0% | $348.2M |
| Roivant Sciences LtdCUSIP G76279101 | March 31, 2026 | +27.8% | $234.3M |
| BLTEBelite Bio Inc | December 31, 2025 | −3.7% | $456.6M |
Sold off last quarter
- DNTHDianthus Therapeutics Inc was $1.5M
Quarter by quarter
| Quarter | Its picks | S&P 500 |
|---|---|---|
| June 30, 2026 | −16.0% | +14.8% |
| March 31, 2026 | −7.8% | −4.6% |
| December 31, 2025 | +25.6% | +2.4% |
| September 30, 2025 | +39.2% | +7.8% |
| June 30, 2025 | +34.3% | +10.5% |
| March 31, 2025 | +7.5% | −4.6% |
| December 31, 2024 | −12.2% | +2.1% |
| September 30, 2024 | +13.9% | +5.4% |
| June 30, 2024 | −15.2% | +4.0% |
| September 30, 2023 | −34.0% | −3.6% |
| June 30, 2023 | +52.6% | +8.3% |
| March 31, 2023 | −3.1% | +7.0% |
| December 31, 2022 | −7.8% | +7.1% |
| September 30, 2022 | −17.0% | −5.3% |
| June 30, 2022 | −0.4% | −16.5% |
| March 31, 2022 | −16.2% | −4.9% |
| September 30, 2021 | +1.7% | +0.3% |
Sources
Every number on this page points here. Each one links to the public record.
- 1SEC EDGAR: Darwin Global Management, Ltd. Form 13F filingshttps://www.sec.gov/cgi-bin/browse-edgar?action=getcompany&CIK=1839209&type=13F-HR&dateb=&owner=include&count=40CIK 1839209
- 2SEC: 13F for the quarter ended June 30, 2026https://www.sec.gov/Archives/edgar/data/1839209/000189268826000126/Filed August 14, 2026 · accession 0001892688-26-000126