1y return+69.8%S&P 500 +20.9%
These returns are for its stock picks as disclosed on Form 13F: last quarter's holdings, valued at this quarter's prices. They miss trades within each quarter, short positions, options, bonds, cash and fees, so they aren't the returns its clients got.
$100 invested in its stock picks
Since March 31, 2025: $161 against $133 in the S&P 500.2
Sarissa Capital Management LPS&P 500 (SPY)
Top holdings
At the end of June 30, 2026. Change is in shares since the quarter before.2
| Stock | Value | Share of portfolio | Change |
|---|---|---|---|
| INVAInnoviva Inc | $42.9M | 24.1% | −11.3% |
| IRWDIronwood Pharmaceuticals Inc | $38.7M | 21.7% | |
| AMRNAmarin Corp PLC | $26.7M | 15.0% | |
| NBIXNeurocrine Biosciences Inc | $19.6M | 11.0% | |
| CYTKCytokinetics Inc | $19.5M | 10.9% | |
| LNTHLantheus Hldgs Inc | $18.5M | 10.4% | |
| Biohaven LtdCUSIP G1110E107 | $8.7M | 4.9% | +3.4% |
| REGNRegeneron Pharmaceuticals | $2.6M | 1.5% | |
| VORVor Biopharma Inc | $468K | 0.3% | |
| BIIBBiogen Inc | $205K | 0.1% | New |
Best picks still held
How each current holding has done since the quarter it first appeared in its filings (up to six years back).
| Stock | Held since | Return since | Now worth |
|---|---|---|---|
| NBIXNeurocrine Biosciences Inc | June 30, 2023 | +78.7% | $19.6M |
| INVAInnoviva Inc | June 30, 2020 | +62.4% | $42.9M |
| Biohaven LtdCUSIP G1110E107 | December 31, 2025 | +31.8% | $8.7M |
| CYTKCytokinetics Inc | March 31, 2024 | +21.5% | $19.5M |
| REGNRegeneron Pharmaceuticals | September 30, 2025 | +10.9% | $2.6M |
| LNTHLantheus Hldgs Inc | September 30, 2024 | +1.1% | $18.5M |
| AMRNAmarin Corp PLC | June 30, 2025 | −1.7% | $26.7M |
Quarter by quarter
| Quarter | Its picks | S&P 500 |
|---|---|---|
| June 30, 2026 | +16.0% | +14.8% |
| March 31, 2026 | +4.8% | −4.6% |
| December 31, 2025 | +24.5% | +2.4% |
| September 30, 2025 | +12.3% | +7.8% |
| June 30, 2025 | −5.3% | +10.5% |
| December 31, 2024 | −1.3% | +2.1% |
| September 30, 2024 | −6.2% | +5.4% |
| June 30, 2024 | −5.6% | +4.0% |
| March 31, 2024 | −12.9% | +10.0% |
| December 31, 2023 | +8.5% | +11.2% |
| September 30, 2023 | −8.3% | −3.6% |
| June 30, 2023 | +4.1% | +8.3% |
| March 31, 2023 | −4.4% | +7.0% |
| December 31, 2022 | +15.1% | +7.1% |
| September 30, 2022 | −10.3% | −5.3% |
| June 30, 2022 | −4.6% | −16.5% |
| March 31, 2022 | +0.8% | −4.9% |
| December 31, 2021 | −13.6% | +10.7% |
| September 30, 2021 | +2.8% | +0.3% |
Sources
Every number on this page points here. Each one links to the public record.
- 1SEC EDGAR: Sarissa Capital Management LP Form 13F filingshttps://www.sec.gov/cgi-bin/browse-edgar?action=getcompany&CIK=1577524&type=13F-HR&dateb=&owner=include&count=40CIK 1577524
- 2SEC: 13F for the quarter ended June 30, 2026https://www.sec.gov/Archives/edgar/data/1577524/000089914026000879/Filed August 14, 2026 · accession 0000899140-26-000879