1y return+66.8%S&P 500 +20.9%
3y return+72.7%S&P 500 +68.5%
5y return+19.9%S&P 500 +74.5%
10y return+360.9%S&P 500 +256.5%
These returns are for its stock picks as disclosed on Form 13F: last quarter's holdings, valued at this quarter's prices. They miss trades within each quarter, short positions, options, bonds, cash and fees, so they aren't the returns its clients got.
$100 invested in its stock picks
Since June 30, 2016: $461 against $357 in the S&P 500.2
Rtw Investments, LPS&P 500 (SPY)
Top holdings
At the end of June 30, 2026. Change is in shares since the quarter before.2
| Stock | Value | Share of portfolio | Change |
|---|---|---|---|
| MDGLMadrigal Pharmaceuticals Inc | $1.1B | 9.1% | |
| ARGXArgenx Se | $658.2M | 5.6% | |
| PTCTPtc Therapeutics Inc | $631.9M | 5.4% | |
| PTGXProtagonist Therapeutics Inc | $620.4M | 5.3% | |
| CGONCg Oncology Inc | $605.0M | 5.2% | +21.9% |
| INSMInsmed Inc | $516.3M | 4.4% | |
| TNGXTango Therapeutics Inc | $434.5M | 3.7% | +4.5% |
| SYRESpyre Therapeutics Inc | $377.5M | 3.2% | +1.9% |
| CELCCelcuity Inc | $345.8M | 3.0% | +8.7% |
| ERASErasca Inc | $328.8M | 2.8% | +11.1% |
| RDNTRadnet Inc | $298.9M | 2.6% | +13.1% |
| ORKAOruka Therapeutics Inc | $298.7M | 2.6% | +52.5% |
| NTRANatera Inc | $271.4M | 2.3% | −20.0% |
| RAREUltragenyx Pharmaceutical In | $260.3M | 2.2% | +113.7% |
| IRTCIrhythm Holdings Inc | $259.6M | 2.2% | +30.8% |
| CYTKCytokinetics Inc | $243.8M | 2.1% | +5.2% |
| KLRAKailera Therapeutics Inc | $237.4M | 2.0% | New |
| Establishment Labs Hldgs IncCUSIP G31249108 | $227.9M | 1.9% | |
| GHGuardant Health Inc | $222.2M | 1.9% | |
| NBIXNeurocrine Biosciences Inc | $213.7M | 1.8% | +19.4% |
| TARSTarsus Pharmaceuticals Inc | $211.3M | 1.8% | |
| STOKStoke Therapeutics Inc | $184.0M | 1.6% | |
| Uniqure NvCUSIP N90064101 | $181.5M | 1.5% | +52.4% |
| ACADAcadia Pharmaceuticals Inc | $180.8M | 1.5% | |
| RGENRepligen Corp | $169.3M | 1.4% | +2.9% |
Best picks still held
How each current holding has done since the quarter it first appeared in its filings (up to six years back).
| Stock | Held since | Return since | Now worth |
|---|---|---|---|
| PTGXProtagonist Therapeutics Inc | June 30, 2020 | +594.1% | $620.4M |
| NTRANatera Inc | June 30, 2020 | +444.4% | $271.4M |
| INSMInsmed Inc | June 30, 2023 | +405.3% | $516.3M |
| Establishment Labs Hldgs IncCUSIP G31249108 | June 30, 2020 | +359.4% | $227.9M |
| SYRESpyre Therapeutics Inc | December 31, 2023 | +312.5% | $377.5M |
| ARGXArgenx Se | June 30, 2020 | +311.9% | $658.2M |
| CYTKCytokinetics Inc | September 30, 2020 | +293.5% | $243.8M |
| ORKAOruka Therapeutics Inc | September 30, 2024 | +288.3% | $298.7M |
| CMPSCompass Pathways PLC | December 31, 2024 | +274.3% | $151.4M |
| TNGXTango Therapeutics Inc | December 31, 2025 | +252.8% | $434.5M |
Sold off last quarter
- Apogee Therapeutics IncCUSIP 03770N101 was $234.2M
- Apellis Pharmaceuticals IncCUSIP 03753U106 was $148.2M
- ISRGIntuitive Surgical Inc was $101.4M
- Centessa Pharmaceuticals PLCCUSIP 152309100 was $81.6M
- Crinetics Pharmaceuticals InCUSIP 22663K107 was $52.7M
- WAYWaystar Hldg Corp was $39.3M
- ARWRArrowhead Pharmaceuticals In was $36.7M
- SYKStryker Corporation was $32.9M
- CMPXCompass Therapeutics Inc was $22.1M
- FLGTFulgent Genetics Inc was $20.5M
Quarter by quarter
| Quarter | Its picks | S&P 500 |
|---|---|---|
| June 30, 2026 | +17.5% | +14.8% |
| March 31, 2026 | −4.2% | −4.6% |
| December 31, 2025 | +21.1% | +2.4% |
| September 30, 2025 | +22.3% | +7.8% |
| June 30, 2025 | +4.1% | +10.5% |
| March 31, 2025 | −2.1% | −4.6% |
| December 31, 2024 | −2.8% | +2.1% |
| September 30, 2024 | +4.6% | +5.4% |
| June 30, 2024 | −8.5% | +4.0% |
| March 31, 2024 | +6.4% | +10.0% |
| December 31, 2023 | +21.5% | +11.2% |
| September 30, 2023 | −15.5% | −3.6% |
| June 30, 2023 | +2.8% | +8.3% |
| March 31, 2023 | −3.9% | +7.0% |
| December 31, 2022 | +8.5% | +7.1% |
| September 30, 2022 | +13.8% | −5.3% |
| June 30, 2022 | −24.0% | −16.5% |
| March 31, 2022 | −16.9% | −4.9% |
| December 31, 2021 | −4.0% | +10.7% |
| September 30, 2021 | −6.0% | +0.3% |
Sources
Every number on this page points here. Each one links to the public record.
- 1SEC EDGAR: Rtw Investments, LP Form 13F filingshttps://www.sec.gov/cgi-bin/browse-edgar?action=getcompany&CIK=1493215&type=13F-HR&dateb=&owner=include&count=40CIK 1493215
- 2SEC: 13F for the quarter ended June 30, 2026https://www.sec.gov/Archives/edgar/data/1493215/000149321526000164/Filed August 14, 2026 · accession 0001493215-26-000164