RARE on Nasdaq

Ultragenyx Pharmaceutical Inc.

We are a biopharmaceutical company committed to bringing novel products to patients for the treatment of serious rare and ultra-rare genetic diseases.3 From its latest annual report

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Last updated Oct 19, 2026.

Overview

Compare with Kiniksa Pharmaceuticals International, plc, Axsome Therapeutics or Amicus Therapeutics, or pick any stock.

  • TickerRARE on Nasdaq1
  • IndustryPharmaceutical Preparations1
  • HeadquartersNovato, California1
  • Incorporated inDE2
  • Business address60 Leveroni Court, Novato, Ca 949492
  • Filer categoryLarge accelerated filer2

We are a biopharmaceutical company committed to bringing novel products to patients for the treatment of serious rare and ultra-rare genetic diseases. We have built a diverse portfolio of approved therapies and product candidates aimed at addressing diseases with high unmet medical need and clear biology for treatment, for which there are typically no approved therapies treating the underlying disease.3 From its latest annual report

Financials

From the company’s reports to the SEC. Every number links to the filing it came from.

Key numbers, fiscal 2025

-79.5%Operating margin4
-85.4%Net margin4
20.2%Revenue growth, 20254
-$472.0MFree cash flow4

What sells

Revenue by product, business segment and region, as the company reports it to the SEC.

Products and services

Product brought in 55% of the revenue Ultragenyx Pharmaceutical Inc. broke down this way in fiscal 2025.

  1. Product$369.0M455%up 29% from 2024
  2. Royalty$304.0M445%up 11% from 2024
Products and services by year
Products and services202320242025
Product$180.0M$285.0M$369.0M
Royalty$183.0M$275.0M$304.0M

Regions

North America brought in 56% of the revenue Ultragenyx Pharmaceutical Inc. broke down this way in fiscal 2025.

  1. North America$377.0M456%up 11% from 2024
  2. Latin America$170.0M425%up 30% from 2024
  3. EMEA$108.0M416%up 35% from 2024
  4. Asia Pacific$18.0M43%up 100% from 2024
Regions by year
Regions202320242025
North America$307.0M$340.0M$377.0M
Latin America$77.0M$131.0M$170.0M
EMEA$48.0M$80.0M$108.0M
Asia Pacific$2.0M$9.0M$18.0M

Where the money goes

Where each dollar of revenue went, fiscal 2025

  • Research and development68¢$750.0M
  • Selling, general and admin32¢$349.0M
  • Income tax0¢$4.0M

Out of $673.0M in revenue.4 The company lost money this year.

Financial statements

Revenue56784$673.0M in 2025+549% since 2019
0$200.0M$400.0M$600.0M$800.0M2019: $103.7M$103.7M20192020: $271.0M$271.0M2020+161%2021: $351.4M$351.4M2021+30%2022: $363.3M$363.3M2022+3%2023: $434.0M$434.0M2023+19%2024: $560.0M$560.0M2024+29%2025: $673.0M$673.0M2025+20%
Operating income56784-$535.0M in 2025+26% since 2019
-$800.0M-$600.0M-$400.0M-$200.0M02019: -$424.2M-$424.2M20192020: -$330.1M-$330.1M2020−22%2021: -$381.7M-$381.7M2021+16%2022: -$648.9M-$648.9M2022+70%2023: -$569.0M-$569.0M2023−12%2024: -$536.0M-$536.0M2024−6%2025: -$535.0M-$535.0M2025−0%
Net income56784-$575.0M in 2025+43% since 2019
-$800.0M-$600.0M-$400.0M-$200.0M02019: -$402.7M-$402.7M20192020: -$186.6M-$186.6M2020−54%2021: -$454.0M-$454.0M2021+143%2022: -$707.4M-$707.4M2022+56%2023: -$607.0M-$607.0M2023−14%2024: -$569.0M-$569.0M2024−6%2025: -$575.0M-$575.0M2025+1%

Every line of the income statement as filed: the last 3 fiscal years, latest first.4

Period ending2025-12-312024-12-312023-12-31
Total revenues$673.0M$560.0M$434.0M
Cost of sales$109.0M$77.0M$45.0M
Research and development$750.0M$698.0M$648.0M
Selling, general and administrative$349.0M$321.0M$310.0M
Total operating expenses$1.2B$1.1B$1.0B
Loss from operations-$535.0M-$536.0M-$569.0M
Interest income$25.0M$37.0M$27.0M
Non-cash interest expense on liabilities for sales of future royalties-$62.0M-$63.0M-$66.0M
Other income (expense)$1.0M-$5.0M-$1.0M
Loss before income taxes-$571.0M-$567.0M-$609.0M
(Provision for) benefit from income taxes-$4.0M-$2.0M$2.0M
Net loss-$575.0M-$569.0M-$607.0M
Net loss per share, basic-$5.83-$6.29-$8.25
Net loss per share, diluted-$5.83-$6.29-$8.25
Shares used in computing net loss per share, Basic98.6M shares90.5M shares73.5M shares
Shares used in computing net loss per share, Diluted98.6M shares90.5M shares73.5M shares

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Leadership

Who has led Ultragenyx Pharmaceutical Inc., and when. Pick a name to see everywhere that person has worked.

Board members and other officers (24)

Timeline

  1. Feb 7, 2014New chief executive Emil D. Kakkis becomes CEO12

Filings

379 filings to the SEC since October 2021: 5 annual reports, 15 quarterly reports, 81 major events, 174 insider forms, 36 large holders, 68 other. The latest 20:

  1. Oct 14, 20268-K EDGAR
  2. Oct 7, 20268-K EDGAR
  3. Sep 17, 20268-K EDGAR
  4. Sep 15, 2026144 EDGAR
  5. Sep 15, 20264 EDGAR
  6. Sep 8, 20264 EDGAR
  7. Sep 2, 20268-K EDGAR
  8. Aug 19, 20268-K EDGAR
  9. Aug 14, 2026SCHEDULE 13G EDGAR
  10. Aug 13, 2026SCHEDULE 13G EDGAR
  11. Aug 11, 20268-K EDGAR
  12. Aug 7, 2026SCHEDULE 13G EDGAR
  13. Aug 5, 202610-Q EDGAR
  14. Aug 4, 20268-K EDGAR
  15. Aug 4, 20264 EDGAR
  16. Aug 4, 20264 EDGAR
  17. Aug 3, 2026144 EDGAR
  18. Jul 31, 2026SCHEDULE 13G/A EDGAR
  19. Jul 31, 2026SCHEDULE 13G EDGAR
  20. Jul 30, 2026SCHEDULE 13G/A EDGAR

The 379 filings since October 2021 can be filtered by form type and year here when JavaScript is on.

Every filing from the last five years, summarized. The full record is on SEC EDGAR.

Insider trades

109 open-market trades by officers, directors and large owners since October 2021: 0 buys and 109 sales. Grants, option exercises and gifts are left out.

DateWhoTradeSharesPriceValueFiling
Sep 15, 2026Huizenga Theodore AlanSVP, Chief Accounting OfficerSale1,283$13.57$17.4KForm 4
Sep 3, 2026Huizenga Theodore AlanSVP, Chief Accounting OfficerSale161$13.99$2.3KForm 4
Aug 3, 2026Parschauer Karah HerdmanEVP and Chief Legal OfficerSale1,900$24.92$47.3KForm 4
Aug 3, 2026Horn HowardChief Financial OfficerSale4,696$24.92$117.0KForm 4
Jul 1, 2026Horn HowardChief Financial OfficerSale4,698$33.13$155.6KForm 4
Jun 15, 2026Sanders Corazon (Corsee) D.DirectorSale2,000$25.05$50.1KForm 4
Jun 15, 2026Parschauer Karah HerdmanEVP and Chief Legal OfficerSale1,899$24.62$46.8KForm 4
Jun 1, 2026Horn HowardChief Financial OfficerSale4,653$23.77$110.6KForm 4
May 18, 2026SULIMAN SHEHNAAZDirectorSale5,740$25.12$144.2KForm 4
May 5, 2026Crombez EricEVP and Chief Medical OfficerSale344$24.96$8.6KForm 4
May 1, 2026Horn HowardChief Financial OfficerSale4,683$24.90$116.6KForm 4
Apr 1, 2026Horn HowardChief Financial OfficerSale4,683$20.97$98.2KForm 4
Mar 10, 2026Parschauer Karah HerdmanEVP and Chief Legal OfficerSale3,508$22.67$79.5KForm 4
Mar 6, 2026Parschauer Karah HerdmanEVP and Chief Legal OfficerSale6,018$21.40$128.8KForm 4
Mar 3, 2026Horn HowardChief Financial OfficerSale1,635$22.40$36.6KForm 4
Mar 2, 2026Pinion John RichardSee RemarksSale10,029$22.80$228.7KForm 4
Mar 2, 2026Harris ErikEVP & Chief Commercial OfficerSale10,539$22.80$240.3KForm 4
Mar 2, 2026KAKKIS EMIL DPresident & CEOSale54,404$22.80$1.2MForm 4
Mar 2, 2026Parschauer Karah HerdmanEVP and Chief Legal OfficerSale8,135$22.80$185.5KForm 4
Mar 2, 2026Huizenga Theodore AlanSVP, Chief Accounting OfficerSale1,632$22.80$37.2KForm 4

All 109 trades can be filtered by person here when JavaScript is on.

From Forms 4 filed with the SEC.

Major holders

Investors who own more than 5% of the shares must tell the SEC: a 13D if they may seek to influence the company, a 13G if they hold passively.

Held by these funds

The largest holders among investment managers' 13F reports for the quarter ending Jun 30, 2026, the top 25 of 100. Change is in shares since the quarter before.

FundSharesValueShare of the fundChange
BlackRock, Inc.10,654,276$355.7M0.0%+3,354,678
Rtw Investments, LP7,796,895$260.3M2.2%+4,148,100
Vanguard Portfolio Management LLC6,790,135$226.7M0.0%+1,404,143
Aqr Capital Management LLC6,560,809$214.1M0.1%+1,982,785
State Street Corp6,158,766$205.6M0.0%+1,137,325
Vanguard Capital Management LLC4,296,491$143.5M0.0%+106,660
Two Sigma Investments, LP3,621,200$120.9M0.1%+1,415,380
Sands Capital Management, LLC3,158,368$105.5M0.4%−56,165
Jacobs Levy Equity Management, Inc2,939,719$98.2M0.4%+1,508,648
Frontier Capital Management Co LLC2,847,936$95.1M0.9%+656,754
Geode Capital Management, LLC2,578,828$86.1M0.0%+729,437
Bellevue Group AG1,982,775$66.2M1.4%−397,225
D. E. Shaw & Co., Inc.1,730,193$57.8M0.0%+469,175
Sofinnova Investments, Inc.1,717,505$57.3M3.1%−1,428,383
Adage Capital Partners Gp, L.l.c.1,580,000$52.8M0.1%+1,100,000
Mpm Bioimpact LLC1,418,215$47.4M2.9%New
Morgan Stanley1,324,805$44.2M0.0%−175,723
Wellington Management Group Llp1,250,464$41.8M0.0%−1,390,348
Voloridge Investment Management, LLC1,241,556$41.5M0.2%−185,278
Bank Of America Corp /de/1,148,454$38.3M0.0%+101,908
Candriam S.C.A.1,001,841$33.4M0.2%−94,341
Rock Springs Capital Management LP967,855$32.3M1.6%−250,918
Jefferies Financial Group Inc.929,626$31.0M0.3%+914,138
Northern Trust Corp920,314$30.7M0.0%+384,748
Eagle Health Investments LP884,121$29.5M4.9%No change

13F reports cover disclosed long positions in U.S. stocks only.

Members of Congress who traded it

5 trades disclosed by members of Congress. “Vs S&P since” is the stock’s change since the trade minus the S&P 500’s.

DateMemberTradeAmountVs S&P sinceFiling
Sep 29, 2026Gilbert Ray Cisneros, Jr.Democratic, HouseBuy$1,001 - $15,000−2.0%Report
Mar 3, 2026Gilbert Ray Cisneros, Jr.Democratic, HouseBuy$1,001 - $15,000−44.7%Report
Feb 18, 2026Gilbert Ray Cisneros, Jr.Democratic, HouseBuy$1,001 - $15,000−38.3%Report
Aug 8, 2025Gilbert Ray Cisneros, Jr.Democratic, HouseBuy$1,001 - $15,000−66.0%Report
Jul 15, 2025Gilbert Ray Cisneros, Jr.Democratic, HouseBuy$1,001 - $15,000−68.3%Report

Members report amounts as ranges, not exact figures. Returns are price-only (no dividends).

Sources

The numbers on this page point here. Each one links to the record it came from.

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