1y return+83.7%S&P 500 +20.9%
3y return+47.5%S&P 500 +68.5%
5y return+33.0%S&P 500 +74.5%
10y return+185.9%S&P 500 +256.5%
These returns are for its stock picks as disclosed on Form 13F: last quarter's holdings, valued at this quarter's prices. They miss trades within each quarter, short positions, options, bonds, cash and fees, so they aren't the returns its clients got.
$100 invested in its stock picks
Since June 30, 2016: $286 against $357 in the S&P 500.2
Sio Capital Management, LLCS&P 500 (SPY)
Top holdings
At the end of June 30, 2026. Change is in shares since the quarter before.2
| Stock | Value | Share of portfolio | Change |
|---|---|---|---|
| AVRAnteris Technologies Global | $54.6M | 9.4% | +3.0% |
| CORCencora Inc | $49.1M | 8.4% | +72.0% |
| MMSMaximus Inc | $38.5M | 6.6% | −7.0% |
| ALLOAllogene Therapeutics Inc | $27.7M | 4.7% | New |
| GMEDGlobus Med Inc | $23.8M | 4.1% | New |
| GSKGsk PLC | $22.9M | 3.9% | +13.2% |
| TYRATyra Biosciences Inc | $22.2M | 3.8% | +14.8% |
| WAYWaystar Hldg Corp | $19.0M | 3.3% | −43.6% |
| IDYAIdeaya Biosciences Inc | $17.9M | 3.1% | New |
| ORKAOruka Therapeutics Inc | $16.9M | 2.9% | +33.7% |
| CIThe Cigna Group | $15.9M | 2.7% | New |
| SNYSanofi Sa | $15.5M | 2.7% | +52.0% |
| Icon Pub Ltd CoCUSIP G4705A100 | $15.3M | 2.6% | −71.2% |
| VTRSViatris Inc | $15.2M | 2.6% | New |
| Cross Ctry Healthcare IncCUSIP 227483104 | $14.5M | 2.5% | |
| RAPPRapport Therapeutics Inc | $12.8M | 2.2% | −16.1% |
| ABTAbbott Laboratories | $11.7M | 2.0% | −31.0% |
| CELCCelcuity Inc | $11.5M | 2.0% | −43.2% |
| ZBHZimmer Biomet Holdings Inc | $11.3M | 1.9% | +109.9% |
| REGNRegeneron Pharmaceuticals | $11.2M | 1.9% | New |
| BMYBristol-myers Squibb Co | $11.1M | 1.9% | New |
| Medtronic PLCCUSIP G5960L103 | $11.1M | 1.9% | New |
| VIRVir Biotechnology Inc | $11.0M | 1.9% | −28.2% |
| SENSSenseonics Hldgs Inc | $9.0M | 1.6% | +1275.6% |
| EYPTEyepoint Inc | $8.9M | 1.5% | −13.7% |
Best picks still held
How each current holding has done since the quarter it first appeared in its filings (up to six years back).
| Stock | Held since | Return since | Now worth |
|---|---|---|---|
| DNTHDianthus Therapeutics Inc | March 31, 2025 | +437.4% | $5.8M |
| ORKAOruka Therapeutics Inc | December 31, 2025 | +214.0% | $16.9M |
| CELCCelcuity Inc | September 30, 2025 | +111.8% | $11.5M |
| SVRASavara Inc | December 31, 2024 | +100.7% | $3.8M |
| DRUGBright Minds Biosciences Inc | December 31, 2024 | +94.9% | $5.2M |
| TYRATyra Biosciences Inc | March 31, 2024 | +94.8% | $22.2M |
| AVRAnteris Technologies Global | December 31, 2024 | +76.5% | $54.6M |
| Cross Ctry Healthcare IncCUSIP 227483104 | December 31, 2025 | +63.1% | $14.5M |
| ANIPAni Pharmaceuticals Inc | December 31, 2024 | +49.7% | $8.1M |
| AQSTAquestive Therapeutics Inc | March 31, 2025 | +43.4% | $6.2M |
Sold off last quarter
- CORTCorcept Therapeutics Inc was $27.2M
- Livanova PLCCUSIP G5509L101 was $26.8M
- EMBCEmbecta Corp was $16.3M
- ABVXAbivax Sa was $15.1M
- HAEHaemonetics Corp Mass was $12.4M
- TFXTeleflex Incorporated was $11.3M
- BMRNBiomarin Pharmaceutical Inc was $11.0M
- GPCRStructure Therapeutics Inc was $10.1M
- Biohaven LtdCUSIP G1110E107 was $9.8M
- MNPRMonopar Therapeutics Inc was $9.5M
Quarter by quarter
| Quarter | Its picks | S&P 500 |
|---|---|---|
| June 30, 2026 | +18.1% | +14.8% |
| March 31, 2026 | −1.6% | −4.6% |
| December 31, 2025 | +22.7% | +2.4% |
| September 30, 2025 | +28.7% | +7.8% |
| June 30, 2025 | −3.2% | +10.5% |
| March 31, 2025 | −13.8% | −4.6% |
| December 31, 2024 | −8.2% | +2.1% |
| September 30, 2024 | +10.0% | +5.4% |
| June 30, 2024 | −8.6% | +4.0% |
| March 31, 2024 | +8.1% | +10.0% |
| December 31, 2023 | +10.7% | +11.2% |
| September 30, 2023 | −12.8% | −3.6% |
| June 30, 2023 | +7.9% | +8.3% |
| March 31, 2023 | −4.0% | +7.0% |
| December 31, 2022 | +10.7% | +7.1% |
| September 30, 2022 | +0.1% | −5.3% |
| June 30, 2022 | −6.6% | −16.5% |
| March 31, 2022 | −5.7% | −4.9% |
| December 31, 2021 | −5.8% | +10.7% |
| September 30, 2021 | −5.3% | +0.3% |
Sources
Every number on this page points here. Each one links to the public record.
- 1SEC EDGAR: Sio Capital Management, LLC Form 13F filingshttps://www.sec.gov/cgi-bin/browse-edgar?action=getcompany&CIK=1482416&type=13F-HR&dateb=&owner=include&count=40CIK 1482416
- 2SEC: 13F for the quarter ended June 30, 2026https://www.sec.gov/Archives/edgar/data/1482416/000121465926010311/Filed August 14, 2026 · accession 0001214659-26-010311