1y return+58.3%S&P 500 +20.9%
3y return+50.0%S&P 500 +68.5%
5y return+7.0%S&P 500 +74.5%
10y return+128.2%S&P 500 +256.5%
These returns are for its stock picks as disclosed on Form 13F: last quarter's holdings, valued at this quarter's prices. They miss trades within each quarter, short positions, options, bonds, cash and fees, so they aren't the returns its clients got.
$100 invested in its stock picks
Since June 30, 2016: $228 against $357 in the S&P 500.2
Rock Springs Capital Management LPS&P 500 (SPY)
Top holdings
At the end of June 30, 2026. Change is in shares since the quarter before.2
| Stock | Value | Share of portfolio | Change |
|---|---|---|---|
| RVMDRevolution Medicines Inc | $207.0M | 10.1% | −8.6% |
| TVTXTravere Therapeutics Inc | $123.8M | 6.0% | +47.4% |
| LLYEli Lilly & Co | $118.4M | 5.8% | |
| MDGLMadrigal Pharmaceuticals Inc | $94.0M | 4.6% | +2.3% |
| MIRMMirum Pharmaceuticals Inc | $93.4M | 4.6% | −1.6% |
| RYTMRhythm Pharmaceuticals Inc | $76.9M | 3.8% | |
| KYMRKymera Therapeutics Inc | $52.0M | 2.5% | −8.8% |
| ARGXArgenx Se | $48.9M | 2.4% | −46.4% |
| Ascendis Pharma A/sCUSIP K08588103 | $45.0M | 2.2% | New |
| XENEXenon Pharmaceuticals Inc | $41.3M | 2.0% | −10.4% |
| SRRKScholar Rock Hldg Corp | $39.3M | 1.9% | −3.3% |
| INSMInsmed Inc | $38.6M | 1.9% | +15.2% |
| PENPenumbra Inc | $36.5M | 1.8% | −3.9% |
| GPCRStructure Therapeutics Inc | $34.4M | 1.7% | |
| RAREUltragenyx Pharmaceutical In | $32.3M | 1.6% | −20.6% |
| IRTCIrhythm Holdings Inc | $32.1M | 1.6% | +3.0% |
| ISRGIntuitive Surgical Inc | $30.4M | 1.5% | −6.8% |
| AGLAgilon Health Inc | $28.1M | 1.4% | +1.0% |
| UNHUnitedhealth Group Inc | $26.5M | 1.3% | +20.3% |
| CLDXCelldex Therapeutics Inc New | $26.0M | 1.3% | +7.5% |
| ERASErasca Inc | $25.7M | 1.3% | +27.1% |
| NBIXNeurocrine Biosciences Inc | $24.4M | 1.2% | −3.8% |
| ELVNEnliven Therapeutics Inc | $23.6M | 1.2% | −43.8% |
| THCTenet Healthcare Corp | $23.4M | 1.1% | |
| DXCMDexcom Inc | $23.1M | 1.1% | −3.5% |
Best picks still held
How each current holding has done since the quarter it first appeared in its filings (up to six years back).
| Stock | Held since | Return since | Now worth |
|---|---|---|---|
| RVMDRevolution Medicines Inc | March 31, 2023 | +764.6% | $207.0M |
| MIRMMirum Pharmaceuticals Inc | June 30, 2020 | +501.6% | $93.4M |
| COGTCogent Biosciences Inc | June 30, 2025 | +439.0% | $20.0M |
| XENEXenon Pharmaceuticals Inc | June 30, 2020 | +381.3% | $41.3M |
| ARGXArgenx Se | June 30, 2020 | +311.9% | $48.9M |
| KYMRKymera Therapeutics Inc | September 30, 2020 | +254.9% | $52.0M |
| MBXMbx Biosciences Inc | September 30, 2025 | +215.4% | $16.5M |
| ELVNEnliven Therapeutics Inc | March 31, 2024 | +188.5% | $23.6M |
| ISRGIntuitive Surgical Inc | June 30, 2020 | +109.4% | $30.4M |
| TVTXTravere Therapeutics Inc | December 31, 2020 | +108.4% | $123.8M |
Sold off last quarter
- Ascendis Pharma A/sCUSIP 04351P101 was $44.4M
- Arcellx IncCUSIP 03940C100 was $19.5M
- Centessa Pharmaceuticals PLCCUSIP 152309100 was $14.0M
- Soleno Therapeutics IncCUSIP 834203309 was $8.6M
- REGNRegeneron Pharmaceuticals was $7.8M
- Apellis Pharmaceuticals IncCUSIP 03753U106 was $6.5M
- Terns Pharmaceuticals IncCUSIP 880881107 was $6.0M
- XBISpdr Series Trust was $3.8M
- EWEdwards Lifesciences Corp was $2.3M
- ACHCAcadia Healthcare Company In was $1.8M
Quarter by quarter
| Quarter | Its picks | S&P 500 |
|---|---|---|
| June 30, 2026 | +19.8% | +14.8% |
| March 31, 2026 | −5.1% | −4.6% |
| December 31, 2025 | +18.0% | +2.4% |
| September 30, 2025 | +17.9% | +7.8% |
| June 30, 2025 | +6.3% | +10.5% |
| March 31, 2025 | −6.5% | −4.6% |
| December 31, 2024 | −5.7% | +2.1% |
| September 30, 2024 | +4.4% | +5.4% |
| June 30, 2024 | −6.1% | +4.0% |
| March 31, 2024 | +1.0% | +10.0% |
| December 31, 2023 | +14.4% | +11.2% |
| September 30, 2023 | −10.7% | −3.6% |
| June 30, 2023 | +4.0% | +8.3% |
| March 31, 2023 | −0.9% | +7.0% |
| December 31, 2022 | +2.8% | +7.1% |
| September 30, 2022 | +7.7% | −5.3% |
| June 30, 2022 | −15.9% | −16.5% |
| March 31, 2022 | −12.2% | −4.9% |
| December 31, 2021 | −8.9% | +10.7% |
| September 30, 2021 | −7.1% | +0.3% |
Sources
Every number on this page points here. Each one links to the public record.
- 1SEC EDGAR: Rock Springs Capital Management LP Form 13F filingshttps://www.sec.gov/cgi-bin/browse-edgar?action=getcompany&CIK=1595725&type=13F-HR&dateb=&owner=include&count=40CIK 1595725
- 2SEC: 13F for the quarter ended June 30, 2026https://www.sec.gov/Archives/edgar/data/1595725/000117266126003527/Filed August 14, 2026 · accession 0001172661-26-003527